Research library
Phosphatidylserine Research Library
Selected source-linked publications for formulation education, organized by study type, application area, population, summary, and limitations.
Animal and Laboratory StudyNeuroscience / Cell Membrane Biology2026
Loss of Atp8a2 drives neurodegeneration through the dysregulation of spatiotemporal phosphatidylserine externalization in mature neurons
Schneider A, Merkel AB, Perta N, Ruff L, Ussyshkin N, Zimmer P, Aksan B, Lepeuve A, D’Andrea L, Pelucchi S, Marcello E, Di Marino D, Mauceri D
Cell Death & Disease · DOI 10.1038/s41419-026-09097-y
- Population
- Cultured mature hippocampal neurons and mouse retinal, optic-nerve, and neurodegeneration models
- Evidence summary
- Using cultured neurons and several mouse models, the study associated reduced Atp8a2 expression with altered phosphatidylserine exposure patterns, loss of neuronal structure, and greater vulnerability, while Atp8a2 overexpression produced model-specific protective effects.
- Limitations
- This mechanistic work studied endogenous membrane phosphatidylserine regulation in cell and mouse models, not dietary supplementation or humans. Acute experimental neurotoxicity and model-specific manipulations limit translation to clinical or nutrition outcomes.
View original source →
Human Clinical StudyMetabolic and Vascular Research2026
Beneficial vascular effects of oral phosphatidylserine supplementation in type 2 diabetes
McMillan NJ, Augenreich MA, Ramirez-Perez FI, Power G, Burr K, Lateef OM, Nagarajan M, Foote CA, Imkaew N, Jurrissen TJ, Lazo-Fernandez Y, Betancourt-Cortes EE, Ferreira-Santos L, Beltran-Ornelas JH, Manrique-Acevedo C, Martinez-Lemus LA, Padilla J
Journal of Applied Physiology · DOI 10.1152/japplphysiol.00281.2026
- Population
- 34 adults with type 2 diabetes; supporting endothelial-cell, isolated-artery, and db/db mouse models
- Evidence summary
- In a four-week randomized, double-blind, placebo-controlled trial embedded in a broader mechanistic study, adults with type 2 diabetes receiving phosphatidylserine showed changes in leg blood-flow response and load-dependent aortic pulse-wave velocity compared with placebo; supporting cell and diabetic-mouse experiments examined ADAM17 and vascular mechanisms.
- Limitations
- The human sample was small (16 phosphatidylserine and 18 placebo), lasted four weeks, enrolled only adults with type 2 diabetes, and evaluated surrogate vascular measures rather than clinical events. Results are specific to the studied 900 mg/day supplement (about 280 mg/day phosphatidylserine) and do not support treatment claims.
View original source →
Laboratory StudyCell Membrane Biology2026
Phosphatidylserine and RhoB connect PI4P and PA metabolism to maintain plasma membrane identity
Huang S, Kim YJ, Cao X, Bumpus TW, Sohn M, Menold MT, Dale RK, Kang JJ, Uematsu S, Gupta S, Qian SB, Yu H, Balla T, Baskin JM
Journal of Cell Biology · DOI 10.1083/jcb.202509213
- Population
- Cultured mammalian cells and biochemical membrane models
- Evidence summary
- In cultured-cell and biochemical experiments, prolonged PI4KA inhibition reduced cellular phosphatidylserine while increasing phospholipase D activity and phosphatidic acid, with RhoB upregulation linked to compensatory membrane and actin changes.
- Limitations
- This is mechanistic laboratory research using pharmacologic and genetic perturbations in cultured systems. It did not test oral phosphatidylserine, finished formulations, whole-animal outcomes, or human health effects.
View original source →
Human Clinical StudyCognitive Health2025
The cognitive effects of supplementation with sunflower phosphatidyl serine in healthy children aged 8 to 12 years: a randomized controlled trial
Friling M, Jackson PA, Kennedy D, Dodd F, Smith E, Lavie A, Lopresti A, Ivanir E, Jalanka J
Nutrition Journal · DOI 10.1186/s12937-025-01264-9
- Population
- Healthy children aged 8 to 12 years
- Evidence summary
- This randomized controlled trial reported no significant overall differences on its primary or secondary outcomes, while exploratory subgroup observations were identified for further research.
- Limitations
- The overall outcomes were not significant. Subgroup observations should not be converted into efficacy or medical claims.
View original source →
Human Clinical StudyHealthy Aging2025
Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial
Duan H, Xu N, Yang T, Wang M, Zhang C, Zhao J, Li Z, Chen Y, Yan J, Zhang M, Li W, Yue Z, Ma F, He R, Huang G
Journal of Affective Disorders · DOI 10.1016/j.jad.2024.09.131
- Population
- Chinese older adults with mild cognitive impairment
- Evidence summary
- The human study reported short-term memory-related findings for a food supplement containing phosphatidylserine in the population studied.
- Limitations
- The study concerns a specific finished supplement and clinical population. Its findings do not establish that a bulk PS ingredient treats cognitive decline.
View original source →
Human Clinical StudySports Nutrition2026
Effects of Taurine-, Caffeine-, and Phosphatidylserine-Containing Supplementation Protocols on Physical and Cognitive Performance in Professional Male Football Players
Mizera K, Mizgała-Izworska E, Mizera J, Mackiewicz J
Nutrients · DOI 10.3390/nu18111684
- Population
- Professional male football players
- Evidence summary
- This human exercise study investigated combined supplementation protocols containing taurine, caffeine, and phosphatidylserine in relation to physical and cognitive performance measures.
- Limitations
- The active protocols contained multiple ingredients and different caffeine doses, so the independent contribution of phosphatidylserine cannot be determined.
View original source →
Human Clinical StudyCognitive Health2026
Differential cognitive effects of DHA-enriched and standard phosphatidylserine formulations in children with ADHD: a randomized, placebo-controlled trial
Jaicks CCD, Kinter RC
Applied Neuropsychology: Child · DOI 10.1080/21622965.2026.2694486
- Population
- Children with ADHD
- Evidence summary
- The randomized study compared DHA-enriched and standard phosphatidylserine formulations across cognitive measures in the population studied.
- Limitations
- This is research in a diagnosed pediatric population using specific finished formulations. It must not be translated into a disease-treatment claim for a bulk ingredient.
View original source →
