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In Vitro Study Shows Lipid Droplet Structure Changes Infant Formula Digestion

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Danone Research and Innovation and the University of Lyon found that larger, milk phospholipid-coated lipid droplets were digested and absorbed differently than standard formula droplets in vitro.

Microscopy-style visual of large and small lipid droplets above an infant formula scoop and milk illustration on a research desk

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Research Setup

Scientists from Danone Research & Innovation and the University of Lyon's CarMeN laboratory simulated infant gastrointestinal digestion in vitro to compare human milk, a standard infant formula, a formula with added milk fat globule membrane, and a novel concept formula made with large, milk phospholipid-coated lipid droplets.

The findings were published in Food Chemistry in 2026 and summarized by Danone Research in a July 2026 press release.

Main Findings

Large and small lipid droplet models beside formula powder and a digestion-study beaker

Larger lipid droplets enriched with phospholipids were broken down very differently compared with the small, simpler droplets typical of standard infant formulas.

The researchers concluded that droplet size and the presence of surface phospholipids affected the rate and extent of lipid digestion and absorption, showing that fat structure, not just composition, shapes early-life lipid handling.

Danone said the team plans to build on the in vitro insights with clinical studies.

구매자 요약

The work adds to the evidence base for structuring infant nutrition around milk phospholipids and MFGM, an area of growing supplier investment.

For ingredient buyers, it reinforces demand for phospholipid-rich dairy fractions and positions structural lipid design as a formulation differentiator in premium infant nutrition.

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